TOXIC EFFECTS OF CARBAMIDE PEROXIDE ON THE DENTIN-PULP COMPLEX

Abstract

The objective of the present study was to evaluate the toxicity of carbamide peroxide on the dentin-pulp complex in the teeth of young, male rats using this medication in different doses that are considered clinical and subclinical. The methodology used was a comparative histological analysis between the control group and the test groups. The test groups were characterized by the ingestion of carbamide peroxide, in different concentrations, in the water supplied to them for a period of 40 days. The concentrations were: 1.9 mg/ml (test 1), 0.95 mg/ml (test 2), 0.71 mg/ml (test 3), 0.47 mg/ml (test 4) and 0.24 mg/ml (test 5). The results in the test groups showed a decrease in the odontoblast layer as well as changes in its morphology,   and thickening of the pre-dentin layer. This demonstrates that different concentrations of carbamide peroxide may cause significant changes in the dentin-pulp complex.